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|Cas:||62 44 2||Purity:||99.9%|
|Usage:||For Lab Research||Payment Method:||T/T, Western Union, MoneyGram, Bitcoin|
Phenacetin Powder Pharmaceutical Raw Materials White Powder Phenacetin Pain Killer Medicine CAS 62 44 2
EINECS Number: 200-533-0
Density: 1.099g / cm3
Melting point: 133-138 ℃
Boiling point: 355.1 ° C at 760 mmHg
Flash Point: 168.5 ° C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses: Anti-inflammatory drugs
Appearance: White or almost white crystalline powder
Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).
It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C.," or "aspirin-phenacetin-caffeine" compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia.
But the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November of 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs. phenacetin
Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.
Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system.
Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis.This is a condition which results in destruction of some or all of the renal papillae in the kidneys.
One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure. High quality best price
Shandong Shengri Chemical Co., Ltd.
Shandong Shengri Chemical Co., Ltd. is located in Shandong province, China.
Shandong Shengri Chemical Co., Ltd. is an experienced enterprise of manufacturing various kind of research chemicals(cannabinoids and stimulant), steroids, Human Growth Hormone HGH, hyaluronic acid and peptide products.
Shandong Shengri Chemical Co., Ltd. research and development center also offers custom synthesis services.
Price, Company and Service Advantage:
1 Best service, high quality and reasonable price
2. It's customers' right to choose the package (EMS, DHL, FedEx, UPS);
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4. Specials are possible when client's order is big enough, including the discount policy;
5. Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship your order;
6. Return policy: we promise we will return your money if our product don't have effect
1.we have over 10 years experience in this aera
2.we can provide competitive price for every customer and guarantee the quality of our goods.
3.we are attention to every customer's requirements and make a good relationship with them.
4.we have a long business relationship with many countries, such as canada, mexico, brazil, united kingdom, russia, germany, india, south africa, malta, egypt, armenia, australia, philippines, belgium, netherlands, denmark ect.
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1. Why Choose Us
1. rich experience
we specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of coroperation with them.
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good quality is one of our biggest secert to success;u can get the best quality and service from us.
3. safest and fastest delivery
we have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.fast and discreet shipment will be arranged to pass customs.
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unique ways to ship 10g to 100kg powders to your destination.we offer melting powder into liquid service and ship the liquid in special bottles.
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Q1: have your product quality been approved by third party lab
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Q2: how do you treat quality complaint
A: first of all, our qc department will do strict examination of our export products by hplc, uv, gc , tlc and so on in order to reduce the quality problem to near zero. if there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: is there any discount
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A:it is depending on your location,
for small order, please expect 5-7 days by dhl,ups,tnt, fedex, ems.
for mass order, please allow 5-8 days by air, 20-35 days by sea.
Q5 do you have any reshipment policy
A: we have good after-sale service and re-shipment policy if the parcel lose.
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